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KMID : 0363220090470101196
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Korean Journal of Dermatology
2009 Volume.47 No. 10 p.1196 ~ p.1198
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Isotretinoin Treatment for the Recalcitrant Acne on a Patient with Apert Syndrome
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Byun Ji-Won
Choi Gwang-Seong
Shin Jeong-Hyun
Song Hee-Jin
Lee Hyeon-Sook
Han Sung-Hyub
Yang Bo-Hee
Lee Seung-Gyu
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Abstract
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Apert syndrome is a rare genetic craniofacial disorder associated with premature fusion of multiple cranial sutures and syndactyly. It is caused by mutation in the fibroblast growth factor receptor 2 genes. The clinical findings are characterized by the typical dysmorphic facial features, including hypertelorism, proptosis and cleft palate. Most of these patients have widespread, severe acne involving the face, chest, back and forearms during puberty and the acne is unresponsive to conventional treatments. We report here on a patient with the recalcitrant acne of Apert syndrome and the patient had failed to respond to conventional acne treatment, but the acne was successfully treated with isotretinoin.
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KEYWORD
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Acne, Apert syndrome, Isotretinoin
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